As shown in panel B, a decrease in PGC‐1α protein content was found in Tg‐CTRL mice with respect to the age‐matched WT‐CTRL mice, in all phases of the disease (although at 14 months of age the difference did not reach statistical significance), suggesting that the basal level of mitochondrial biogenesis was impaired by CHF. The gene discussed is PPARGC1A; the disease is congestive heart failure.