Possible mechanisms linking diabetes with cancer include hyperglycemia and hyperinsulinemia (endogenous or exogenous), plus alterations of the insulin‐like growth factor system, chronic subclinical inflammation, abnormalities in sex hormone metabolism, adipokines and possibly antidiabetes medication used in the management of type 2 diabetes28, 29, 30, 31, 32, 33, 34, 35, 36. This evidence concerns the gene PLXNA3 and diabetes mellitus.