APLN and lung carcinoma: To be able to experimentally dissect the role of Apelin in lung cancer, Apln−/− mice were crossed to the Lox‐Stop‐Lox‐KRasG12D lung cancer model (KRas;Apln+/y and KRas;Apln−/y hereafter; the Apelin gene is located on the X chromosome; Kuba et al, 2007) (Jackson, 2001).