The buildup of insoluble oligomeric forms and gradual deposition of filamentous aggregated tau protein into intraneuronal pretangles and neurofibrillary tangles (NFTs) characterize all tauopathies (Bodea, Eckert, Ittner, Piguet, & Götz, 2016; Morris, Maeda, Vossel, & Mucke, 2011). Here, MAPT is linked to tauopathy.