Both in vitro and in the brain stem of JNPL3 mice, SM07883 reduced the phosphorylation all tested tau epitopes, all of which have been found highly phosphorylated in AD brains (Martin et al., 2015; Neddens et al., 2018; Oliveira, Costa, de Almeida, da Cruz e Silva, & Henriques, 2017; Šimić et al., 2016). Here, MAPT is linked to Alzheimer disease.