Due to its localization on chromosome 21, the DYRK1A gene is 1.5‐fold overexpressed in DS and increased activity of DYRK1A has been correlated with abnormal brain development, cognitive disabilities, and an early onset of AD in individuals with DS (Becker, Soppa, & Tejedor, 2014). This evidence concerns the gene DYRK1A and Alzheimer disease.