Furthermore, IVLBCL, splenic DLBCL, and primary bone marrow DLBCL often share common clinical, laboratory and immunophenotypic features, including unexplained fever, absence of prominent lymphadenopathy, splenomegaly, high levels of serum LDH and sIL2R, and CD5 positivity. This evidence concerns the gene CD5 and Splenomegaly.