ERCC8 and Cowden syndrome 1: Cockayne syndromes can result from mutations in either the excision repair cross-complementation group 6 (ERCC6) gene or the ERCC8 gene involved in repairing damaged DNA, but early reports found no obvious genotype-phenotype correlations for mutations in either ERCC8 or ERCC6, suggesting that the clinical variability within the CS spectrum may not be accounted for gene mutation alone [112].