Interestingly, iNOS has potent antimicrobial activities and inhibits the spread of murine CMV, but overexpression of iNOS can also damage RPE cells, change neovascularization in ischemic retinopathy, and is associated with the severity of diabetic retinopathy in mice and humans [16, 19, 40]. The gene discussed is NOS2; the disease is diabetic retinopathy.