CTLA4 and neoplasm: Recent studies have demonstrated that anti-CTLA-4 mAbs confer their CITE by selective depletion of Treg within the tumor microenvironment (TME) through antibody-dependent cellular cytotoxicity/antibody-dependent cellular phagocytosis (ADCC/ADCP).29–32,40–42 It is therefore of interest to consider how pH sensitivity affects the ADCC activity of anti-CTLA-4 antibodies.