CTLA4 and autoimmune disease: Previous investigations demonstrated that LRBA plays an essential role in protecting CTLA-4 from being sorted to lysosomes for degradation, and promoting CTLA-4 recycling to the cell surface.36 Since patients with a LRBA mutation develop autoimmune diseases,36 we evaluated if irAE-prone anti-CTLA-4 antibodies interfere with CTLA-4 recycling.