Denaturing immunoprecipitations revealed that endogenous levels of sumoylated SENP2 were observed in the EBV-positive B-cells but not their EBV-negative counterparts or the control immunoprecipitations, which suggests that SENP2 is endogenously sumoylated during latent EBV infections. This evidence concerns the gene SENP2 and Epstein-Barr virus infection.