The PyMT/OTUD3 KO mice showed enhanced rate of cell proliferation, angiogenesis, and dampened rate of cell apoptosis in tumor formation compared with that of the the PyMT/OTUD3 WT mice, as indicated by the Ki67, CD31 and cleaved-Caspase-3 staining (Fig. 1g). The gene discussed is PECAM1; the disease is neoplasm.