CASP3 and neoplasm: Importantly, tumor sections from KrasG12D/WT/OTUD3 KO mice exhibited decreased cell proliferation, shrinked angiogenesis, and accumulated cell apoptosis signals than that of tumor tissues from KrasG12D/WT/OTUD3 WT mice, as indicated with the Ki67, CD31, and cleaved Caspase-3 staining (Supplementary Fig. 1m).