In our study, we describes a PTEN protector OTUD3 discards the regulation of PTEN and turns to maintain the stability of an oncoprotein GRP78 in lung cancer, and deletion of OTUD3 in mice decreased development of lung carcinomas, implicating the tissue complexity of deubiquitylase in the development of tumor. The gene discussed is OTUD3; the disease is lung carcinoma.