OTUD3 and neoplasm: Following analysis demonstrated that KrasG12D/WT/OTUD3 TG mice displayed more detectable nodules, larger tumor area, higher tumor grades than KrasG12D/WT/OTUD3 WT mice in the lung and exhibited poorer overall survival than those bearing tumors with normal expression level of OTUD3 (Fig. 1l–n and Supplementary Fig. 2c–f).