Consistent with our previous finding in breast cancer, the expression levels of OTUD3 and PTEN were decreased in hepatocellular cancer, colon cancer, and cervical cancer, compared with the matched adjacent normal tissues, and the expression of OTUD3 was closely related to PTEN expression in hepatocellular cancer, colon cancer, and cervical cancer (Fig. 2a–i). This evidence concerns the gene PTEN and malignant colon neoplasm.