Acetylation of TDP-43, a RNA-binding protein that is found in SGs72, undergoes LLPS in vitro8,9,47 and aggregates into insoluble deposits in the brain of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration73, promotes TDP-43 aggregation into SGs, while HDAC6-dependent deacetylation of TDP-43 reduces SG formation70. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.