Interestingly, we found that upregulation of multiple HOXB genes was unique to the combination of N + LTB, as it did not occur for N in combination with any of the other T-ALL oncogenes tested (LYL1, TLX1, TLX3, HOXA9, MEF2C, NKX2.1) (Supplementary Fig. 9). This evidence concerns the gene TLX3 and acute lymphoblastic leukemia.