In 22/24 recipients injected with hCD45+ G+C+ cells (FACS sorted from day 24–25 N+ LTB-transduced CB cultures), we obtained G+C+ leukemias of T-cell lineage, typically CD7+ CD2+ sCD3+/− CD1a+/− and variable CD4/CD8 pattern including CD4− CD8− (DN), CD4+ CD8+ (DP), and CD4− CD8dim (SP8dim) (Supplementary Fig. 3, Supplementary Data 1). The gene discussed is CD4; the disease is leukemia.