Following on evidence that HOXB gene upregulation occurred as an early event in NLTB-transduced CB cells, we examined RNA-seq data from established CB leukemias and a collection of T-ALL PDXs and found HOXB2/B3/B4 mRNA levels were coordinately elevated in both contexts (Fig. 8a). This evidence concerns the gene HOXB2 and acute lymphoblastic leukemia.