Phosphorylated VEGFR2 (p-VEGFR2) recruits VE-cadherin (VE-cad)/β-catenin/actin to regulate F-actin cytoskeletal remodeling in ECs, altering vascular remodeling, thereby promoting the normalization of tumor microvessel networks and improving the tumor microenvironment. This evidence concerns the gene CDH5 and neoplasm.