To investigate the molecular mechanisms underlying reduced tumor cell proliferation upon TET1 KD in human T-ALL cells, we measured DNA (hydroxy)methylation and RNA expression changes, using MeDIP-, hMeDIP-, and RNA-seq analysis, comparing CCRF-CEM cells before (SCR) and upon TET1 KD (TET1sh) (Fig. 5). Here, TET1 is linked to acute lymphoblastic leukemia.