MYC and acute lymphoblastic leukemia: To determine the effect MYC inactivation in tumors has on DNA methylation (5mC) and hydroxymethylation (5hmC), we carried out methylated DNA immunoprecipitation (MeDIP- and hMeDIP-seq, respectively) analysis, taking advantage of the tetracycline-regulated c-myc allele in T-ALL cells derived from EμSRα-tTAα;tet-o-MYC mice (Fig. 1).