The tumor cells were positive for CD10 (luminal pattern), p16INK4a (non-block staining pattern), PAX2 (Fig. 1b, c, d), inhibin, cytokeratin 7, WT-1, wild-type p53 (images not shown), and negative for estrogen receptors, progesterone receptors, cytokeratin 20, CEAm, and calretinin (images not shown). The gene discussed is ESR1; the disease is neoplasm.