A supervised outdoor running program, three times a week for 10 weeks, resulted in significant improvements in the social dimension of HrQoL (IBDQ social dimension p = .03) but showed no changes in disease activity (Crohn’s Disease Activity Index (CDAI) p = .81; Rachmilewitz Index (RI) p = .88) or laboratory parameters (Leucocyte count (Lc) p = .39, C-reactive protein (CRP) p = .88, fecal calprotectin (FCP) p = .90) [36]. The gene discussed is CRP; the disease is Crohn disease.