The SCLC-transformed tumors also exhibited high rate of CNS metastases and median OS since initial diagnosis of advanced lung cancer and after SCLC-transformation of 31.5 and 10.9 months, respectively, which together with the frequent but transient responses to platinum-etoposide are clinical features reminiscent of those in classic smoking-associated SCLC with wt EGFR [195]. The gene discussed is EGFR; the disease is lung carcinoma.