Indeed, the transcription factors (TFs) Twist, Snail, Slug and ZEB1, which regulate a plethora of genes associated with a mesenchymal cellular phenotype, can be found upregulated in NSCLC cells before therapy or are rapidly induced by EGFR-TKIs as part of the adaptive cellular reprogramming. This evidence concerns the gene EGFR and non-small cell lung carcinoma.