Furthermore, large-scale miR-profiling of serum samples from NSCLC patients treated with EGFR-TKIs showed that among 153 differentially expressed microRNAs, miR-21, AmiR-27a, and miR-218 were significantly upregulated in patients showing no response to these drugs as compared to sensitive patients, suggesting that these three microRNAs may also be implicated in intrinsic resistance to EGFR-TKIs [262]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.