EGFR and adenosquamous carcinoma: Given that diagnostic biopsies are small and taken from single sites, it cannot be excluded though, that some of the cases described as SqCC-conversion of EGFRM+ LACs, in fact were at baseline EGFRM+ adenosquamous carcinomas, which are known to harbor EGFR-mutations in both components [241] and could have progressed through further clonal selection of the SqCC-population [240].