However, in NSCLC NRAS- and KRAS-mutations not only display a distinct nucleotide transversion profile, but also a different position, in that 80% of NRAS-mutations affect codon Q61 and 20% codon G12, while >90% of KRAS-mutations occur in codon G12, 6% in codon G13, and only 2% in codon Q61 [151]. The gene discussed is NRAS; the disease is non-small cell lung carcinoma.