Indeed, overexpression of the EMT-related zinc-finger transcriptional repressor ZEB1 in EGFRM+ NSCLC cell lines inhibits the expression of E-cadherin by recruiting histone deacetylases (HDACs), and this renders these cells insensitive to EGFR-TKIs [207]. The gene discussed is ZEB1; the disease is non-small cell lung carcinoma.