CXCL8 and neoplasm: It has also been suggested that activation of NF-κB is associated with inflammatory signaling and tumor development, such as upregulation of COX-2 and nitric oxide synthase; up-regulation of the inflammatory cytokines IL-6, IL-8, and TNF-a; and upregulation of the chemokines CCL2 and CXCL8 [20,21].