In particular, changes induced by MM-EV-derived miR-146a in BM-MSCs include Notch1 activation and the release of cytokines, in addition to chemokines such as IL-6, IL-8, CXCL1, IP-10, CCL2, and CCL5, which favor MM cell growth, viability, and migration [78,79]. This evidence concerns the gene CXCL8 and Miyoshi myopathy.