The first observation in multiple myeloma is that MM-EVs are able to carry several pro- and anti-inflammatory cytokine and chemokines, i.e., IL-6, CCL2 [15], IL-15 [83], IL-7 [67], IL-32 [58], IL-10 and IL-16 [92], and VEGF [42]. This evidence concerns the gene CCL2 and Miyoshi myopathy.