Alike autoantibody levels in pristane-induced lupus (Figure 1b, Supplement Figure S1a,b), in one of two independent experiments we observed an increase in anti-CII IgG in WT compared to RAGE−/− mice, while anti-CII IgG2a and anti-CII IgG1 subclasses, as well as the anti-CII IgG1/IgG2a ratio, did not differ between the groups (Figure 3b, Supplement Figure S4b). Here, AGER is linked to systemic lupus erythematosus.