Moreover, in TLR2- and TLR4-deficient C57BL/6lpr/lpr, as well as pristane-injected TLR4-deficient animals, development of murine lupus, was mitigated, while TLR2 and TLR4 activation enhanced disease [45,46,47,48]. The gene discussed is TLR4; the disease is systemic lupus erythematosus.