In other studies, OLE has been used as an anti-diabetic agent [33], improved several bone biomarkers in postmenopausal women with osteopenia [12], decreased HbA1c in diabetic patients [34], improved insulin sensitivity in overweight men [16], and blunted acutely post-prandial glucose spikes in the blood when consumed together with sucrose [13]. This evidence concerns the gene INS and Osteopenia.