Since the discovery of carcinoembryonic antigen (CEA) in 1965 as tumor-specific antigen in human colonic carcinoma, research on this family of proteins has mounted, in particular focusing on one of its members, the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) plasma membrane glycoprotein [1]. Here, CEACAM5 is linked to colon carcinoma.