MET and cancer: For instance, PHA-665752 was such a small molecule that it could act as the ATP competitive inhibitor of the catalytic activity of c-Met kinase.60, 61 It has been reported that PHA-665752 could act on the growth and motility of multiple cancer cell lines.62, 63, 64 In the GDSC dataset, the number of cell lines with known response to PHA-665752 is 381, out of which only two cell lines are related to MET amplification.