In summary, the data suggest that highly virulent P. brasiliensis complex isolates that caused disseminated disease in a murine model of PCM expressed high levels of common proteins, such as phosphoglycerate kinase, RNA binding protein, glyceraldehyde-3-phosphate dehydrogenase, glutathione reductase, fructose-bisphosphate aldolase, nucleic acid-binding protein, peroxisomal catalase, and aldehyde dehydrogenase. This evidence concerns the gene GAPDH and paracoccidioidomycosis.