SELENOS and diabetic kidney disease: Meanwhile, in vitro induction of high‐level SEPS1 expressed by islet β‐cell (Min6) may increase resistance to H2O2 injury and enhance cell viability, thus suggesting that SEPS1 is a protective factor in islets with the ability to protect islet β cells from oxidative stress damage.17 Diabetic nephropathy mainly manifests as impaired glomerular filtration capacity, which is essentially the damage of glomerular capillary endothelial cells.