RNA-seq demonstrated that Hh-mediated transcription in skin CD4+ T cells on induction of AD increased expression of immunoregulatory genes (including Ptgs2, Il10, Klrg1, Areg, and Fgl2) and decreased expression of inflammatory and migratory genes (Tnfrsf9, Il1a, Tgif1, Ccr7, Ccr9, Ccl20, and Ccl24). This evidence concerns the gene AREG and Alzheimer disease.