The proportion of naive (CD62L+CD44–) CD4+ T cells was elevated, whereas the T effector memory (Teff) (CD62L–CD44+) and T central memory (Tcm) (CD62L+CD44+) cells were decreased in both CD4+ and CD8+ populations in dLNs from Oxa-treated Gli2ΔN2 compared with Oxa-treated WT mice (Supplemental Figure 4B), consistent with the fact that Teff and Tcm populations are increased in AD patients (33). This evidence concerns the gene CD8A and Alzheimer disease.