PKM and cancer: PKM2 is highly expressed in tumour cells and in many proliferative tissues, and has critical roles in cancer metabolism that remain under intense investigation (Allen and Locasale, 2018; Anastasiou et al., 2011; Christofk et al., 2008a; Dayton et al., 2016), as well as in controlling systemic metabolic homeostasis and inflammation (Palsson-McDermott et al., 2015; Xie et al., 2016; Qi et al., 2017).