PKM and neoplasm: Small-molecule activators, which render PKM2 constitutively active by overcoming endogenous inhibitory cues, attenuate tumour growth, suggesting that regulation of PKM2 activity, rather than increased PKM2 expression per se, is important (Anastasiou et al., 2011; Anastasiou et al., 2012; Wang et al., 2017a; Kim et al., 2015).