Study had shown that UPF1 could promote TGF‐β signalling and inhibits neural differentiation by targeting Smad7 mRNA,16 thus, we hypothesize that SNAI3‐AS1 promotes HCC cell invasion by regulating the ability of UPF1 to mediate the TGF‐β/Smad pathway. This evidence concerns the gene UPF1 and hepatocellular carcinoma.