At the same time, UPF1 can also function as RBP.29, 30 UPF1 not only acts on RNA degradation but also plays a key role in tumour progression.31, 32 Studies showed that UPF1 can induce the degradation of NMD substrate of Smad7 and stimulate TGF signalling, which may be one of the mechanisms regulating HCC metastasis.33 In this study, by bioinformatics analysis and follow‐up experimental verification, we identified a specific interaction between SNAI3‐AS1 and UPF1. Here, PTGDR is linked to hepatocellular carcinoma.