As shown in Figure 1, we found the expressions of CYP2D6 were significantly up‐regulated in large cell lung carcinoma, AC and SCC patients compared with the normal samples (P < 0.05), and CYP24A1 and CYP20A1 were found overexpressed in the AC (P < 0.05). This evidence concerns the gene CYP2D6 and lung large cell carcinoma.