FOXO3 and ischemia: Combined deletion of FoxO1 and FoxO3 specifically in cardiomyocytes results in increased cardiac injury following acute ischemia and reperfusion in vivo, suggesting that FoxO1 and FoxO3 protect the heart from oxidative stress (Sengupta, Molkentin, Paik, DePinho, & Yutzey, 2011).