TGFB1 and neoplasm: Such phenomenon has been described for long time.32 The suppressive role of this signalling in cancers reflects in inhibition on tumour formation and inducement of growth arrest and apoptosis.33, 34 On the other hand, TGF‐β/SMAD signalling shows the activity to promote tumour progression and metastasis, by inducing angiogenesis, inflammation and EMT.35, 36 Yoshida and the colleagues 31 have concluded, based on the reviews of the publications, that TGF‐β acts as a growth suppressor in normal epithelial cells after transient Ras activation.