MAOA and Alzheimer disease: Compound 1 (AV-1451) showed high affinity binding to MAO-A (pIC50 = 7.7) in mouse brain homogenate, which was similar to the high affinity, displaceable binding observed for [3H]AV-1451 in non-AD cortical brain homogenates (Kd ~5–10 nM) [35].