The plasma levels of NT-proBNP were significantly higher in patients who had AF at baseline, with a median of 3417 pg/mL (1897–6486), as compared with patients who were in SR at baseline; both those who had a history of AF (1788 pg/mL [682–3870], p < 0.001) and those who never had AF before (1588 pg/mL [902–5270], p < 0.001) (Table 1), also after multivariable adjustment (Table 2). The gene discussed is NPPB; the disease is atrial fibrillation.