FGFR1 and lobular breast carcinoma in situ: Interestingly, of the nine ILC tumors with amplification at 8p12-11.2, three (33%) had co-amplification with 11q13-q14.1, as previously reported (Fig. 1c).11,12,35 This event was shown recently to be a co-evolution, and likely an early, critical event in tumorigenesis.35 FISH analysis using gene-specific probes for FGFR1 (8p11) and CCND1 (11q13.3) (GISTIC-identified putative driver genes Supplementary Table 2; Fig. 1h), confirmed this co-amplification event in a tumor from the UQCCR cohort, including in an adjacent component of Lobular Carcinoma in situ (LCIS; Fig. 1d–g).