The study of idiopathic pulmonary arterial hypertension (IPAH) pathogenesis revealed that vasoconstriction due to PASMC contraction and pulmonary vascular remodeling as the result of increased PASMC proliferation, growth, and migration are developed because of upregulation of TRPV1 channels. The gene discussed is TRPV1; the disease is idiopathic pulmonary arterial hypertension.