TRPV1 and obesity due to melanocortin 4 receptor deficiency: Currently, TRPV1 is implicated in multiple physiological and pathophysiological processes including pain [10]; thermosensation [11]; energy homeostasis [12]; modulation of autophagy and proteasome activity [13]; reciprocal crosstalk between the sensory nervous and immune systems [14]; regulation of diet-induced obesity; insulin and leptin resistance [15]; cancer [16, 17]; the development severe bronchial asthma [18]; and even in itch and inflammation [19].