Although, one group found that muscle content of both TLR4 and MyD88 proteins are greater in obese, anabolic resistant adults compared with healthy-weight controls (62), discerning the impact of obesity or low-grade inflammation on differences in the postprandial muscle protein synthetic response is not possible from the experiment described above. The gene discussed is TLR4; the disease is obesity due to melanocortin 4 receptor deficiency.