According to the western blot results, bcl-2, cox-2, and fak were down-regulated whereas caspase-3, caspase-9, p-53, nf-kb, and bax were upregulated in osteosarcoma cells in response to CC/Se-HAp nanoparticles treatment as compared to control (Figure 7C). Here, BCL2 is linked to osteosarcoma.