Restoration of Gstp1 expression in LLC-SD-shMek1/2 cells reversed the cisplatin sensitive phenotype seen in LLC-SD-shMek1/2 cells to cisplatin resistance seen in shMek1/2+OEGstp1 cells, measured by Cck-8 proliferation assay (Figure 5C) and the apoptosis assay (Figure 5D) in vitro, and the tumor transplantation assay in vivo (Figure 5E). This evidence concerns the gene GSTP1 and neoplasm.