Chromosomal translocations resulting in chimeric gene fusions such as RUNX1-RUNX1T1, CBFB-MYH11, KMT2A, BCR-ABL1, DEK-NUP214, NUP98-NSD1, GATA2, and MECOM are the important determinants of outcome in AML (2). The gene discussed is RUNX1; the disease is acute myeloid leukemia.