(1) Asthma, (2) Presence of fleeting or fixed pulmonary opacities on chest radiograph, (3) Immediate cutaneous hypersensitivity reaction to Af, (4) Total serum IgE elevated, more than 1000 IU/mL, (5) Precipitating antibodies against Af, (6) Peripheral blood eosinophilia, (7) Central or proximal bronchiectasis with normal tapering of distal bronchi. This evidence concerns the gene IGHE and asthma.