ITSN1 and dementia: For these reasons, we hypothesised that protein levels of both ITSN1 and regulator of calcineurin-1 RCAN1 would be altered in AD brain tissues, and may also be altered in related conditions, including Dementia with Lewy bodies (DLB) and non-Alzheimer’s disease dementia (non-AD; including corticobasal degeneration and supranuclear palsy).