Although our results did not show a significant change in the levels of ITSN1 in the AD brain or the other types of dementia, statistical power analysis revealed that if the number of samples was increased to 35 or more per group, the result might reach statistical significance (this would also potentially help overcome issues around varying PMI times and the limited “snapshot” that comes from analysing individuals from an isolated age range). This evidence concerns the gene ITSN1 and Alzheimer disease.