Because calpain has been shown to cleave cytoskeletal proteins and induce platelet death, it is possible that the interaction between HIT-immune complexes and the FcγRIIA receptor contributes to clearance of platelets from the circulation, thus exaggerating thrombocytopenia, in addition to platelet consumption during microthrombosis7. This evidence concerns the gene DNM2 and Thrombocytopenia.