Germline variants in mesothelioma have previously been reported with a frequency of 10–12% in patients.49,51 In concordance with previous studies, the majority of the mutated genes were involved in HR (BAP1, BRCA2, FANCA, FANCC, FANCD2, and FANCM) and a single gene was involved in nucleotide excision repair (XPC). The gene discussed is FANCD2; the disease is mesothelioma.