BRCA1 and ovarian cancer: Until 2017, the National Comprehensive Cancer Network (NCCN) guidelines stated that the ideal age at which to undergo RRSO was from 35 to 40 years of age, after the patient has had children, regardless of BRCA status; however, the guidelines were revised and now RRSO can be delayed until the patient reaches 40 to 45 years old, since the age of ovarian cancer onset in BRCA2-positive patients is 8 to 10 years older than the mean age of onset in BRCA1-positive patients.