Prostaglandin of the J series including 15deoxy 12,14PGJ2 (PPARG ligand) induces apoptosis in breast cancer cell line by binding to PPRE response (through binding to PPARG) which suggests that peroxisomal proliferator receptor element (PPRE) mediated signaling is essentially required to initiate apoptosis in cancerous cells (Clay et al., 2001). The gene discussed is PPARG; the disease is breast carcinoma.