Recently, immunohistochemical detection of S-100B protein, Glial Fibrillary Acidic Protein (GFAP), synaptophysin or chromogranin-A (CgA) have been studied in oral tissues, such as bundles of human dental pulp; this allowed to find potential different locations of such markers, depending from the presence of physiological or inflamed pulp; these markers have also been investigated about their use for the determination of local inflammation (4) and rare forms of oral cancer (5). This evidence concerns the gene GFAP and lip and oral cavity carcinoma.