Furthermore, the apoptosis and cell proliferation were found to be regulated in 3-MA-treated GnRH-OE Panc1 cells (Figures 4F,G), suggesting that autophagy-related apoptosis might be involved, at least partially, in the anti-proliferative activity of GnRH in pancreatic cancer cells. This evidence concerns the gene GNRH1 and familial pancreatic carcinoma.