In addition, Zoptarelin Doxorubicin treatment can result in apoptosis in GnRH receptor-positive MiaPaCa-2 and Panc1 human pancreatic cancer cells (28), which is similar to our finding that GnRH overexpression can induce apoptosis in Panc1 cells (Figures 3A,B). Here, GNRH1 is linked to pancreatic neoplasm.