Our results demonstrated that Beclin 1 expression and conversion of the cytosolic form of LC3B-I to its lipidated membrane-bound form LC3B-II were increased in the Panc1 cell GnRH-OE group (Figures 4A–C), suggesting that autophagy may be involved in GnRH-mediated apoptosis in pancreatic cancer cells. This evidence concerns the gene GNRH1 and familial pancreatic carcinoma.