GNRHR and familial pancreatic carcinoma: In addition, Zoptarelin Doxorubicin treatment can result in apoptosis in GnRH receptor-positive MiaPaCa-2 and Panc1 human pancreatic cancer cells (28), which is similar to our finding that GnRH overexpression can induce apoptosis in Panc1 cells (Figures 3A,B).