In the present study, our results indicated the abnormal expression of GnRH in advanced pancreatic cancer specimens (Figure 1), and the overexpression and inhibition of GnRH was highly involved in the proliferation in Panc1 cells (Figure 2), suggesting that GnRH might play an important role in tumourigenesis in patients with pancreatic cancer. Here, GNRH1 is linked to familial pancreatic carcinoma.