Furthermore, multiple molecules (e.g., apelin, HDAC4, RCAN1, α-synuclein), altered in stroke are implicated in aging process, premature disorders (e.g., Down syndrome, Werner syndrome) and age-related disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease) (37, 38, 52–66). This evidence concerns the gene APLN and Stroke.