Previous studies demonstrated that HLA-B*15:02 is specifically associated with CBZ-induced SJS/TEN, HLA-A*24:02 is commonly associated with AEDs-induced SJS/TEN in the Han Chinese (13, 35), HLA-A*24:02 may be associated with the cross-reactivity of DRESS/MPE induced by PHT and LTG, and HLA-B*38:01 may be a major responsible allele for the cross-reactivity of SJS/TEN induced by PHT and LTG in Spanish people (36). This evidence concerns the gene HLA-A and toxic epidermal necrolysis.