SDHD and preeclampsia: While neither NDUFA4 nor SDHD have been associated with preeclampsia or placental dysfunction, a decrease in ISCU mRNA has been shown in the preeclamptic placenta (Muralimanoharan et al., 2012) and miR-210 has been shown to directly reduce ISCU expression in both Swan 71 and BeWo trophoblast cells lines resulting in siderosomal/intracellular iron accumulation and a reduction in Swan 71 cell invasion (Lee et al., 2011).